Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer

Stoichiometric Representation of Gene–Protein–Reaction Associations Leverages Constraint-Based Analysis from Reaction to Gene-Level Phenotype Prediction

Genome-scale metabolic reconstructions are currently available for hundreds of organisms. Constraint-based modeling enables the analysis of the phenotypic landscape of these organisms, predicting the response to genetic and environmental perturbations. However, since constraint-based models can only describe the metabolic phenotype at the reaction level, understanding the mechanistic link betwe...

Prostate Specific Antigen Level in Exposure to Sulfur Mustard

Background: Oxidants and inflammation agents are predisposing factors for the development of prostate cancer. As a chemical warfare, sulfur mustard (SM) can cause cancer through various pathways mainly increased production of oxidants and inflammation. Due to high incidence of cancer in SM victims, concentration of prostate specific antigen (PSA) in SM victims was evaluated and compared with th...

Solutions to Enhance the Farmers’ Participation in Water Users Associations (WUAs) in Lorestan Province, Iran

Water Users Association (WUAs) is one of the methods of participatory water resource management whose success and efficiency requires the participation of farmers. Purpose of this study was to identify and prioritize the solutions for farmers’ participation enhancing in WUAs. This exploratory article was carried out by the mixed methods design. The qualitative part of the study was conducted by...

Chronic Exposure to Morphine Leads to a Reduced Affective Pain Response in the Presence of Hyperalgesia in an Animal Model of Empathy

Background: Empathy is the capability to represent the mental and emotional states of other subjects.Previous studies have demonstrated a possible correlation between morphine addiction and altered empathyresponse in morphine-addicted subjects. This study was performed to evaluate the effect of chronic morphineexposure as an animal model of morphine addiction on empathic changes in affective an...

Oxidative DNA Damage and Pro-inflammatory Response In Chronic Exposure To Cement Dust